The IBG-1 develops cutting edge microfluidic lap-on-a-chip technology to investigate cellular growth and development on the very single-cell level. The Modeling and Simulation Group uses time-lapse videos of developing populations for data-driven modelling of biological processes.
Single-cell time-lapse microscopy has revealed heterogeneity of isogenic cells in their response to environmental changes. However, the reasons for the variability are diverse and the mechanisms that trigger the variability vastly unknown. Unravelling aspects of this question with state-of-the-art microfluidic tools in combination with image analysis and modelling has a tremendous value for basic as well as industrial research.
You will investigate physiological processes by means of growth, cell cycle, morphology and fluorescent signals with the microbial platform organisms like Escherichia coli or Corynebacterium glutamicum. You will use state-of-the-art image analysis tools and develop statistical or dynamic models to describe the data.
Specific projects are available with more modelling, computational or image analysis related focus. Ideally, the project is combined with a practical semester. Ideally the project is combined with a practical semester to acquire hands-on experiences with all steps involved in performing single-cell experiments.