The German Cancer Research Center (DKFZ) in Heidelberg, Germany, invites application for a highly motivated and creative PhD student to explore the molecular bases underlying metabolic reprogramming in cancer.
Cancer cells display profound metabolic alterations that enable them to meet the metabolic needs required for various aspects of malignancy. Understanding this metabolic remodeling is essential to decipher the fundamental mechanisms of tumorgenesis, as well as to find novel therapeutic solutions. Iron is a trace element important for many cellular functions and like other metabolic pathways, iron homeostatic mechanisms are frequently altered in cancer (Torti and Torti, Nat. Rev. Cancer, 2013).
In this project, we will make use of state-of-the-art tumor mouse models together with organoid cultures and various cell and molecular biology approaches to investigate the role of central regulatory networks of iron homeostasis in tumor biology, with a particular interest for intestinal cancers.